Withdrawal: Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.

Abstract

Palmitoylation of MPP1 (Membrane-palmitoylated Protein 1)/p55 Is Crucial for Lateral Membrane Organization in Erythroid CellsJournal of Biological ChemistryVol. 287Issue 23PreviewBackground: Lateral membrane organization is important in many essential cellular functions. Results: Lack of palmitoylation of normal or unknown anemia erythrocyte membrane proteins, specifically MPP1, leads to changes in lateral membrane organization. Conclusion: Palmitoylation of MPP1 is crucial for membrane organization and is linked to the pathogenesis of hemolytic anemia. Significance: This might be the first mechanism of biological control of membrane lateral organization. Full-Text PDF Open Access VOLUME 287 (2012) PAGES 18974–18984 This article has been withdrawn by the authors following concerns raised about data integrity in supplemental Figs. S1 and S2 prepared by one of the authors. Although these results are only of supportive nature and do not affect the main results and conclusions presented in the published paper, which were supported additionally by later findings in several experimental systems and published in other papers from 2013 to 2017. Nevertheless, we believe that the responsible course of action is to withdraw the article in the interests of maintaining the publication standards of the journal. We apologize for any inconvenience this may have caused. Download .pdf (.62 MB) Help with pdf files