Abstract
GINS Is a DNA Polymerase ϵ Accessory Factor during Chromosomal DNA Replication in Budding YeastJournal of Biological ChemistryVol. 281Issue 30PreviewGINS is a protein complex found in eukaryotic cells that is composed of Sld5p, Psf1p, Psf2p, and Psf3p. GINS polypeptides are highly conserved in eukaryotes, and the GINS complex is required for chromosomal DNA replication in yeasts and Xenopus egg. This study reports purification and biochemical characterization of GINS from Saccharomyces cerevisiae. The results presented here demonstrate that GINS forms a 1:1 complex with DNA polymerase ϵ (Pol ϵ) holoenzyme and greatly stimulates its catalytic activity in vitro. Full-Text PDF Open Access 21422-21432 This article has been withdrawn at the authors' request.
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