Abstract
Withdrawal effect of Chlorpromazine and Diazepam on chick blood (Plasma, Red Blood Cell) Acetyl cholinesterase activity
Highlights
Acetyl cholinesterase (AChE) is a membrane bound enzyme found in different tissues and play a important role for regulation of most physiological event, involving the turnover of acetylcholine [1,2,3]
It is evident from the results that the enzyme activity were increased at a significant level in both blood plasma and red blood cell by 43% and 63% respectively in group received chlorpromazine, and only 10% and 13% respectively in group received diazepam on day 22.i.e. one day after withdrawal of the drugs
Restoration of the normal level of the enzyme activity has been obtained at certain time interval
Summary
Acetyl cholinesterase (AChE) is a membrane bound enzyme found in different tissues and play a important role for regulation of most physiological event, involving the turnover of acetylcholine [1,2,3]. The activity of blood and/or 'true' AChE have been found to be affected by a number of antipsychotic drugs[1,4,5,6,7,8,9].Chronic treatment of rat and/or chicks with chlorpromazine and diazepam resulted increase in AChE activity[4,5]. Similar finding were obtained from enzyme assay of chick and rabbit brain and cerebrospinal fluid [10].The effect by chlorpromazine in true AChE activity appear to be reversible [1], depending on the duration of drug administration [11]. The aim of the present study is to examine the probability of reversible effect of chlorpromazine and diazepam on red blood cell ‘true’AChE and plasma‘pseudo’AChE activity in chicks
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