Abstract
Abstract Six withanolides ( 1 – 6 ), as well as two known withanolides (physachenolide D 7 and withanoside VI 8 ), were isolated from the aerial parts of Physalis coztomatl (Solanaceae). Structural elucidations of 1 – 6 were achieved through 2D NMR and other spectroscopic techniques, while the structure of 1 was confirmed by X-ray crystallographic analysis. In addition, the stereochemical orientation of the 17-hydroxy group in withanolides was discussed in relation to 13 C NMR shifts of C-12, 13, 14 and 16. Such analysis established that coagulansin A contains a 17 α -hydroxy moiety rather than the reported 17 β -hydroxy functionality, and has been revised accordingly.
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