Abstract
AbstractWithania frutescens (W. frutescens) is a medicinal plant that is largely used in the Morrocan pharmacopeia for disease treatment. This work was conducted to investigate the chemical characterization, analgesic, anti-inflammatory, and healing activities of W. frutescens. The chemical characterization of W. frutescens extract was done using HPLC; the anti-inflammatory test was performed with doses 300, 400 and 450 mg/kg, and the healing activity was assessed using two creams (extract 5% and extract 10%). Phytochemical analysis revealed the presence of phenolic compounds. The results of the anti-inflammatory test were more pronounced when compared with the reference drug with a maximum inhibition percentage of 82.20% ± 8.69 obtained at the dose of 450 mg/kg. Local application of 10% plant cream induced 80.17% ± 7.89 of inflammation inhibition when compared with the indomethacin drug 92.33% ± 11.27. The studied plant extract showed a promising healing activity with the following percentage: 99.03% ± 0.76 (extract 10%), 98.61% ± 1.91 (extract 5%), and 57.43% ± 2.97 (control); meanwhile, the value reached to 100% ± 0.02 for the drug that was used as a reference within the first 2 weeks. The plant studied in this work would be a promising source for conceptualizing effective drugs against inflammatory diseases.
Highlights
Morocco is a very old nation with a very rich civilization and culture and related to herbal medicine [1]
Some active ingredients derived from medicinal plants are applied in many sectors, such as cosmetics, perfumery, aromatherapy, pharmaceuticals, and food processing as well as in the hygiene and sanitary industries [3]
The analysis of the hydro-ethanol extract of W. frutescens was carried out to identify different phenolic compounds of the plant (Figure 3), which confirmed the presence of polyphenols and phenolic acids that inhibition percentage (%) Inhibition percentage (%)
Summary
Morocco is a very old nation with a very rich civilization and culture and related to herbal medicine [1]. The empirical use of different traditional herbal preparations is extremely important for effective candidate plants for further ethnobotanical and pharmacological studies [2]. Some active ingredients derived from medicinal plants are applied in many sectors, such as cosmetics, perfumery, aromatherapy, pharmaceuticals, and food processing as well as in the hygiene and sanitary industries [3]. The therapeutic effects of medicinal plants pave the way for their use in medicine and the pharmaceutical industries in the prevention or treatment of certain infectious, cardiovascular, inflammatory, neurodegenerative, cancerous, and other diseases. The use of alternative medicine practice is explained by several reasons including the high cost of modern medicine, socio-cultural practices of populations, and the need for treatment options for resistant pathogens using alternative agents derived from plants [4]
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