Wirelessly Heating Stents via Radiofrequency Resonance toward Enabling Endovascular Hyperthermia.

Abstract

Thermal therapy known as hyperthermia has served as an effective method for cancer treatment. This therapeutic approach has also been attracting attention for treatment of in-stent restenosis, the most common complication of stenting. Mild heating of stents has been shown to be a possible path to addressing this problem. Despite various studies on stent-based thermotherapy, this area still lacks a clinically viable method and technology. Here, a radiofrequency-powered "hot" stent prototype is reported in vitro and in vivo. An implantable stent device based on medical-grade stainless steel acts as an electrical resonator, or an efficient wireless heater operating only when resonated using tuned external electromagnetic fields. The system architecture uses a custom-developed power transmitter for wireless resonant powering/heating of the stent. An eight-shaped antenna is shown to be highly effective for near-field power transfer to the device and potentially to other smart implants, revealing stent heating efficiencies of up to 120 °C W-1 , 206% of the level provided by a conventional loop antenna. Testing with swine models, the prototyped system achieves stent heating in blood flow by powering through air and skin tissue in vivo in a fully controlled manner. The results advance stent hyperthermia technology toward possible future clinical application.