Abstract

The continuous monitoring of electrical brain activity with implanted electrodes is essential for understanding the neural substrates of many physiological and pathological brain functions. Although this is done in some patients before undergoing surgical treatment, such recordings are extremely difficult in experimental animals, particularly in small rodents. The wires from the implanted electrodes restrain and interfere with the natural behavior of the animals. Consequently, it has been impossible to correlate truly normal behavior with neuronal activity. In addition, it would be ideal if brain activity could be monitored while animals live in a natural and enriched environment. Because of the complexity of such environments with natural hiding places and burrows, recordings of brain activity with wires attached to the animal's skull are impossible. Triangle BioSystems Inc. (TBSI) has overcome these challenges with the design of a miniature, multi‐channel wireless recording system with selectable gain and bandpass filtering. This will give rise to greatly expanded experimental capabilities, and serve as a platform for the development of clinical neural prosthetic devices to treat a variety of ailments including: Alzheimer's disease, epilepsy, and Parkinson's disease.

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