Abstract
A Wireless Amplified NMR Detector (WAND) with cylindrical symmetry has been fabricated and non-surgically inserted into a rodent lower digestive track to improve the imaging quality of deep-lying vessels inside the abdominal cavity. This symmetric detector has a compact design using two end-rings and two vertical legs to create two orthogonal resonance modes. Based on the principle of parametric amplification, the detector can harvest wireless pumping power with its end-rings and amplify Magnetic Resonance signals induced on its vertical legs. With good longitudinal and azimuthal homogeneity, the WAND can achieve up to 21-times sensitivity gain over a standard external detector for immediately adjacent regions, and at least 5-times sensitivity gain for regions separated by one diameter away from the detector’s cylindrical surface. The WAND can approach the region of interest through the lower digestive track, similar as a colonoscopy detector. But unlike an optical camera, the amplified MR detector can “see” across intestinal boundaries and clearly identify the walls of bifurcated vessels that are susceptible to atherosclerotic lesions. In addition to vascular wall imaging, this detector may also be used as a swallowable capsule to enhance the detection sensitivity of deep-lying organs near the digestive track.
Highlights
Magnetic Resonance Imaging (MRI) can diagnose soft tissues lesions based on subtle changes of signal intensity in their pathological states
In the future, when the Wireless Amplified NMR Detector (WAND) is used as a swallowable device that can travel tortuously through the entire digestive track, its wireless amplification capability will still remain effective for the majority of orientations, as long as the detector’s long axis is not perfectly perpendicular to the pumping field
The detection sensitivity of abdominal vessels can be greatly improved with a cylindrically symmetric Wireless Amplified NMR Detector (WAND) that can approach the region of interest through non-surgical insertion into the lower digestive track
Summary
Magnetic Resonance Imaging (MRI) can diagnose soft tissues lesions based on subtle changes of signal intensity in their pathological states. The WAND was initially developed as an implantable detector to identify individual nephrons in vivo[9, 10] It was later used inside the esophagus to sensitively observe vascular walls in the neck and chest regions[11]. A new detector design with cylindrical symmetry is introduced to improve detection homogeneity This symmetric detector can be non-surgically inserted from the rectal to sensitively image vascular walls that are deep lying inside the abdominal cavity, without the need for orientation adjustment. For regions that are farther away, the detector has at least 5 times sensitivity gain even when the distance separation between the region of interest and the detector’s cylindrical surface is large than its own diameter Such detection capability enables high resolution imaging of bifurcated vessels with improved quality, paving way for longitudinal studies of subtle lesions on vascular walls. This wireless detector could potentially be used as swallowable pill that can travel inside tortuous small intestines to “see” across intestinal walls at real time
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
