Winning The Battle Against HIV-1

Abstract

Objective: To present an entirely new theory and practical solution to completely eliminate HIV-1 from the human body, based on a combination between a HAART regimen (HAART-x) and a corresponding, pre-administrated-to-(HAART-x), therapeutic vaccine (Vaccine-x) made of short HIV-1 DNA-sequences containing the point-mutations (resistance-mutations-pattern) that would be induced into HIV-1's genome by the corresponding, following, to come, HAART regimen (HAART-x). Design and methods: HIV-1's ability and need to mutate under HAART pressure is exploited, and the synergetical scissoring effect on HIV-1 of each (Vaccine, HAART)-couple is used to eradicate HIV-1 from the human body. Knowing in advance, the HIV-1 resistance mutations pattern for each antiretroviral drug, and also for any HAART or Mega-HAART regimen, (e.g. from Stanford University HIV Drug Resistance Database, http://hivdb.stanford.edu/ ), HIV-1 DNA therapeutic vaccines can be designed, produced and administrated to HIV-1 positive patients, prior to their usual, corresponding HAART regimens, and these HIV-1 DNA therapeutic vaccines prevent and hinder the emergence of drug-resistant HIV-1 (or HAART-resistant HIV-1), and thus contribute together with HAART, to the eradication of HIV-1 from the human body, and cure AIDS. Results:The general HIV-1 eradication scheme is a succession, or series, of (Vaccine-x, HAART-x)-couples: (Vaccine-1, HAART-1 ) ---> (Vaccine-2 , HAART-2) ---> (Vaccine-3 , HAART-3 ) --->........---> (Vaccine-x , HAART-x) --->........--> (Vaccine-n , HAART-n)---> Eradication and indicates that each therapeutic-vaccine (Vaccine-x) is pre-administrated to its corresponding (HAART-x) regimen. Also, each anti HIV-1 therapeutic-vaccine (Vaccine-x) is made of short HIV-1 DNA sequences which contain the pointmutations (resistance-mutations-pattern) that would be induced into HIV-1's genome by the corresponding, following, to come, HAART regimen (HAART-x). Conclusions: HIV-1 can be be eliminated from the human body, by treatment with successive (Vaccine-x, HAART-x)-couples, followed by (Vaccine-x , Mega-HAART-x)-couples