Abstract
Until now, endovascular treatment of symptomatic atherosclerotic stenosis in small intracranial arteries (≤2.5 mm) was limited. We evaluated the safety and efficacy of the treatment by using Wingspan stents in arteries of this caliber. From March 2007 to July 2010, 53 symptomatic intracranial stenoses with narrowing of at least 50% in 53 patients were treated by using Wingspan stents. Clinical manifestations and imaging features were recorded. The technical success rate was 98.1%. There were no serious complications, with the exception of 1 patient who experienced a small cerebral hemorrhage caused by perforation of microwire. Thirty-nine patients (74%) were available for follow-up imaging with DSA. ISR was documented in 13 of these patients, including 2 patients with symptomatic ISR. The median length of the vascular lesions was 5.39 mm, and patients whose vascular lesions were longer than 5.39 mm had a much higher incidence of ISR than patients whose vascular lesions were shorter than 5.39 mm (53% versus 15%, respectively). The median ratio of the reference artery diameter to the stent diameter was 0.78, and patients whose ratio was smaller than 0.78 had a much higher incidence of ISR than patients whose ratio was larger than 0.78 (53% versus 15%, respectively). In our series, percutaneous transluminal angioplasty and stent placement of small intracranial arteries by using Wingspan stents was safe. The ISR rate was relatively high; most patients having ISR were asymptomatic. Further follow-up is needed to assess the long-term efficacy of this procedure.
Highlights
AND PURPOSE: Until now, endovascular treatment of symptomatic atherosclerotic stenosis in small intracranial arteries (Յ2.5 mm) was limited
MATERIALS AND METHODS: From March 2007 to July 2010, 53 symptomatic intracranial stenoses with narrowing of at least 50% in 53 patients were treated by using Wingspan stents
PTAS is an important method for treating atherosclerotic stenosis in intracranial arteries, and preliminary results suggest that this procedure is safe and effective
Summary
From March 2007 to July 2010, 53 symptomatic intracranial stenoses with narrowing of at least 50% in 53 patients were treated by using Wingspan stents. Patients and Techniques We reviewed patients with symptomatic atherosclerotic stenosis in small intracranial arteries (Յ2.5 mm) treated with Wingspan stents in our hospital during a 41-month period from March 2007 to July 2010. Measurement bias is always inevitable, so we performed a t test for the 2 sets of data and found no statistically significant difference (P Ͼ .05). Discrete lesions treated in the same vascular distribution were counted as a single patient with 2 treated lesions, and the stents were evaluated independently for ISR. If lesions were treated in 2 separate vascular distributions in 1 patient, that patient was counted twice, with each stent evaluated independently for ISR. The data were analyzed by using SPSS 16.0 software
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