Abstract
ObjectivesType 2 diabetes mellitus (T2DM) is sustained by insulin resistance (IR) and reduced β-cell mass, which is largely due to insulin secretory dysfunction. Wnt5a protein is essential to islet formation and β-cell migration in the development of pancreas in vertebrates. Levels of the Wnt5a protein antagonist plasma secreted frizzled-related protein 5 (Sfrp5) were elevated in patients with T2DM. However, the association between Wnt5a, T2DM patients and diabetic kidney disease (DKD) is unknown. We aim to investigate the circulating Wnt5a levels in in different clinical stages of T2DM and evaluate its correlation of duration of diabetes mellitus chronic complication.MethodsA total of 329 participants (187 males, 142 females; age range 40 to 80 years) were enrolled in this study. Serum Wnt5a levels were measured by an enzyme-linked immunosorbent assay (ELISA). The demographic and clinical parameters evaluated in subjects with new onset T2DM, onset T2DM after treatment and DKD at different clinical phases.ResultsWnt5a was significantly down-regulated in newly diagnosed T2DM patients and gradually increased after 3 months of treatment. Interesting, serum wnt5a was gradually increased in patients with long-term diabetes and kidney disease compared to patients with T2DM and onset DKD.ConclusionsWe speculated that the Wnt5a protein might regulate islet function and be involved in the onset of diabetes as a protective factor. It may be one of the inflammatory factors adversely involved in the progression of diabetic nephropathy.
Highlights
Type 2 diabetes mellitus (T2DM) is one of the most prevalent metabolic disorders in the world, with an estimated 113.9 million adults in China, and we can clearly see that the incidence rate is dramatically rising with time [1]
Non-normally distributed values are presented as medians (IQR)
The BMIs were significantly higher in the two diabetic patient groups (27.9 ± 9.28 and 25.4 ± 4.03 for onset T2DM and diabetic kidney disease (DKD), respectively) than in the control group (22.1 ± 3.54)
Summary
Type 2 diabetes mellitus (T2DM) is one of the most prevalent metabolic disorders in the world, with an estimated 113.9 million adults in China, and we can clearly see that the incidence rate is dramatically rising with time [1]. The prevalence rate for prediabetes among Chinese adults reported a rate of over 50% [2]. This metabolic disorder affects health and quality of life, but can bring serious physical, psychological and economical burdens to individuals and governments for a variety of chronic complications, such as macrovascular and microvascular complications. Among these complications, renal involvement occurs in a subset of diabetic patients, often playing a key role in morbidity and mortality [3]. Previous studies have shown that low-grade chronic inflammation and activation of the renin-angiotensin system
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