Abstract
• Obesity is associated with inflammation and oxidative stress. • Wine pomace-polyphenols have anti-inflammatory and antioxidant actions. • Wine pomace (WP) intake reduces fat accumulation in high-fat fed rats. • WP decrease pro-inflammatory cytokines (TNFα and IL1β) • WP increased healthy/harmful microbiota ratio. Obesity is associated with inflammation and oxidative stress. Bioactive compounds can decrease obesity-related disorders by their antioxidant and anti-inflammatory actions. Wistar rats were fed with a high-fat diet during 14 weeks and received 100 mg of wine pomace product (WP)/kg body weight, from the 1st week or from the 7th week and standard diet fed rats were included. Food intake, body weight, blood pressure and plasma glucose, cholesterol and triglyceride were weekly measured. Antioxidant and lipid liver status, fat, adipocyte size, plasma interleukins and microbiota were also determined at 14th week. The results showed a significant reduction of body weight and abdominal fat area, lower blood glucose, decreased liver weight and lipids deposition with increased antioxidant status, lower adipocyte size and increased Lactobacillus spp./ Bacteroides spp. ratio. Therefore, wine pomace product reduced obesity-related disorders by amelioration of inflammation and oxidative stress and by microbiota regulation suggesting potential preventive clinical benefits.
Highlights
Obesity is a multifactorial and inflammatory disease that is associated to several health disorders including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, cancer and cardiovascular complications
We evaluated the effect of the supplementation with 100 mg of wine pomace product (WP)/kg/d on disorders associated with the obesity induced by high-fat-diet in Wistar rats
Energy ingestion was higher in all groups of highfat diet (HF) rats from the beginning of the experiment compared with the Standard Diet group (SD)
Summary
Obesity is a multifactorial and inflammatory disease that is associated to several health disorders including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, cancer and cardiovascular complications. Other factor that contributes to the pathogenesis of the obesity is the oxidative stress by stimulating the deposition of adipose tissue and altering food intake (Manna & Jain, 2015) In this sense, the combination of oxidative stress, dysregulation of adipokines and other factors associated to obesity (i.e. insulin resistance, lipotoxicity, gut microbiota alterations) are responsible of lipid accumulation in the hepatocytes leading to hepatocyte injury, fibrosis, and chronic liver disease (Polyzos, Kountouras, & Mantzoros, 2019). The combination of oxidative stress, dysregulation of adipokines and other factors associated to obesity (i.e. insulin resistance, lipotoxicity, gut microbiota alterations) are responsible of lipid accumulation in the hepatocytes leading to hepatocyte injury, fibrosis, and chronic liver disease (Polyzos, Kountouras, & Mantzoros, 2019) It is known the role of the reactive oxygen species (ROS) in the development of the obesity (Lechuga-Sancho et al, 2018; Rani, Deep, Singh, Palle, & Yadav, 2016)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
