Abstract
The patterns of 5-methylcytosine (5mC) and its oxidized derivatives, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine (5caC) are reportedly altered in a range of cancers. Likewise, Wilms' Tumor protein 1 (WT1), a transcription factor essential for urogenital, epicardium, and kidney development exhibits aberrant expression in multiple tumors. Interestingly, WT1 directly interacts with TET proteins that catalyze the enzymatic oxidation of 5mC and exhibits high affinity for 5caC-containing DNA substrates in vitro. Here we review recent developments in the fields of Tet-dependent 5mC oxidation and WT1 biology and explore potential perspectives for studying the interplay between TETs and WT1 in brain tumors.
Highlights
Reviewed by: Abhijit Shukla, Memorial Sloan Kettering Cancer Center, United States Michelle Lacey, Tulane University, United States
Inactivating mutations occurring in Wilms’ Tumor protein 1 (WT1) during embryonic kidney development result in the formation of the pediatric renal neoplasm Wilms’ tumor (WT) (Pritchard-Jones et al, 1990)
At 11 dpc, WT1 expression is detected in the metanephric mesenchyme, presumptive spinal cord motor neurons, gonads, and ureter (Armstrong et al, 1993)
Summary
Reviewed by: Abhijit Shukla, Memorial Sloan Kettering Cancer Center, United States Michelle Lacey, Tulane University, United States. Wilms’ Tumor protein 1 (WT1) is a Kruppel-like transcription factor important for development of the mammalian embryonic kidney, urogenital system and epicardium (Roberts, 2005) that exhibits developmental and tissue specific expression patterns in mammals (Dressler, 2009; Hastie, 2017).
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