Abstract
Background Wilms tumor is the most common pediatric renal tumor, with unique pathogenesis and histology. Objectives To determine the histopathological pattern of Wilms tumor in relation to demographic data and clinical course. Patients and methods This is a descriptive retrospective case series based study of 51 Wilms tumor patients conducted over 4 years in two centers in Sudan. Paraffin embeded blocks, slides and clinical data of cases were reviewed. Results The patients’ ages ranged from 0.5 to 10 years with the mean age 3.4 years (±SD 2.1) and a male to female ratio of 1.6:1.0. Triphasic tumor was found in 82.2% of patients. Anaplasia was seen in age group 2-6 years. It was related to locally infiltrative tumor and capsular invasion (p value <0.5 and <0.02). Stage III, was found in 43% patients. Stage of disease showed significant relationship to capsular invasion (p<0.03). Conclusion Triphasic tumor is the most common histopathological pattern. Stage III is the most common presentation of Wilms tumor. Capsular invasion strongly associated with the presence of metastasis. Wilms tumor is the most common pediatric renal tumor, with unique pathogenesis and histology. To determine the histopathological pattern of Wilms tumor in relation to demographic data and clinical course. This is a descriptive retrospective case series based study of 51 Wilms tumor patients conducted over 4 years in two centers in Sudan. Paraffin embeded blocks, slides and clinical data of cases were reviewed. The patients’ ages ranged from 0.5 to 10 years with the mean age 3.4 years (±SD 2.1) and a male to female ratio of 1.6:1.0. Triphasic tumor was found in 82.2% of patients. Anaplasia was seen in age group 2-6 years. It was related to locally infiltrative tumor and capsular invasion (p value <0.5 and <0.02). Stage III, was found in 43% patients. Stage of disease showed significant relationship to capsular invasion (p<0.03). Triphasic tumor is the most common histopathological pattern. Stage III is the most common presentation of Wilms tumor. Capsular invasion strongly associated with the presence of metastasis.
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