Abstract
Though proposed as a promising target antigen for cancer immunotherapy, the prognostic value of Wilms' tumor 1 (WT1) in solid tumors remains inconclusive. Here, we report a systematic review and meta-analysis of the association between WT1 expression and prognosis in solid tumors. PubMed, Web of Science and Google Scholar were searched to identify studies exploring the impact of WT1 on clinical outcomes, including overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), relapse/recurrence-free survival (RFS) or progression-free survival (PFS), in solid cancer patients. Hazard ratio (HR) and 95% confidence interval (CI) were applied to assess the strength of these associations. Finally, a total of 29 eligible studies with 4090 patients were identified for qualitative analysis, and 22 studies with 3620 patients were enrolled for quantitative synthesis. Overall, positive expression of WT1 was significantly associated with worse OS (metaHR = 1.48, 95% CI = 1.11–1.97) and DFS/RFS/PFS (metaHR = 2.14, 95% CI = 1.42–3.21). Subgroup analyses showed that WT1 positive expression could independently predict unfavorable DFS/RFS/PFS (metaHR = 1.86, 95%CI = 1.04–3.35). In summary, our study suggests that WT1 may be a potential marker to predict DFS/RFS/PFS in solid tumor patients. Further studies are needed to confirm the role of WT1 expression in clinical practice.
Highlights
Though proposed as a promising target antigen for cancer immunotherapy, the prognostic value of Wilms’ tumor 1 (WT1) in solid tumors remains inconclusive
Positive expression of WT1 was significantly associated with worse overall survival (OS) and disease-free survival (DFS)/recurrence-free survival (RFS)/progression-free survival (PFS)
Twenty-nine datasets reported an adverse impact of WT1 positive expression on prognosis regardless of the statistic power, while, 3 datasets (2 for NSCLC and 1 for soft tissue sarcoma) reported opposite results
Summary
Wilms’ tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis. Xiao-wei Qi1,2, Fan Zhang[1], Hong Wu3, Jun-lan Liu[1], Bei-ge Zong[1], Chuan Xu2,4 & Jun Jiang[1]
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