Wills' Biochemical Basis of Medicine

Abstract

Part 1 Biochemistry of the cell and its metabolism: ultrastructure of the mammalian cell roles of extracellular and intracellular membranes - membrane structure and membrane transport role of subcellular organelles - lysosomes peroxisomes metabolism in the cytosol mitochondria and energy conservation inter-relationships of the mitochondria and cytosol the nucleus the endoplasmic reticulum. Part 2 Whole body metabolism: nutrition - general aspects - energy requirements and the supply of energy by oxidation of foodstuffs - proteins in the diet - dietary fats - vitamins - inorganic constituents of the diet digestion and absorption of foodstuffs hormones - a summary of their structures and functions plasma glucose and its regulation plasma lipids and their regulation plasma amino acids and utilization of amino acids by the tissues plasma electrolytes plasma calcium and phosphate - regulation by Vitamin D and parathyroid hormone starvation. Part 3 Specialized metabolism of tissues: blood - erythropoiesis - role of folate and vitamin B12 - metabolism in the red blood cell - blood clotting - catabolism of haemoglobin - iron and iron metabolism functions of the liver the kidney muscle bone and collagen - calcification the brain and the central nervous system the eye. Part 4 Environmental hazards - detoxication: toxicology - general aspects toxic metals metabolism of xenobiotics - xenobiochemistry alcohol - effects on metabolism carcinogenesis. Part 5 Biochemical basis of diagnosis - disease and its treatment: biochemical diagnosis an example of metabolic disturbance - obesity biochemical genetics - inborn errors of metabolism principles of chemotherapy. Apppendices: Commonly occuring mono- and disaccharides polysaccharides - starch and glycogen glycosaminoglycans (mucopolysaccharides) - proteoglycans naturally occurring a-amino acids lipid chemistry and classification phospholipids purine and pyrimidine bases nucleosides - nucleotides glycolysis pentose phosphate pathway - outline of stages citric acid cycle b-oxidation of fatty acids in mitochondrium biosynthesis of cholesterol summary of amino acid metabolism ornithine cycle - synthesis of urea the genetic code transfer of RNAs steps in eukaryotic protein synthesis.