Abstract
To shed light on which cases of pure autonomic failure will convert to a synucleinopathy (Parkinson disease, dementia with Lewy bodies, or multiple system atrophy), investigators prospectively followed 74 patients from five U.S. medical centers for 5 years. Mean age was 68, there was documented pre-existing autonomic failure for a mean of 5 years. Follow-up at 4 years revealed that 25 patients (34%) had a new diagnosis of dementia with Lewy bodies (13 patients), Parkinson disease …
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