Abstract
The aim of the study is to compare hematoxylin and eosin (H&E) stained tissue sections with Papanicolaou-stained (PAP-stained) tissue sections. Paraffin block tissue sections of five oral pathologies were prepared and stained routinely with H&E and PAP stains. The results of the stained slides revealed a marked difference in staining with respect to color balance, contrast and intensity between H&E and PAP stains. Areas of keratinization were stained from shades of orange to pink depending on the degree of keratinization. In moderately differentiated squamous cell carcinoma, areas of keratin pearl formation and individual cell keratinzation were clearly demonstrated; these were not apparent in the H&E stained slides. The review of this study suggest that the PAP stain more clearly demonstrated key morphological features, associated with keratinization, and it may be considered as a supplemental staining procedure, aiding in diagnosis.
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