Abstract
GENERAL COMMENTARY article Front. Neurol., 24 February 2015Sec. Movement Disorders Volume 6 - 2015 | https://doi.org/10.3389/fneur.2015.00035
Highlights
A commentary on Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases by Riley BE, Lougheed JC, Callaway K, Velasquez M, Brecht E, Nguyen L, et al Nat Commun (2013) 4:1982. doi:10.1038/ ncomms2982
Parkin mutations are responsible for 50% of autosomal recessive juvenile Parkinson’s disease (PD) and 15% of young onset (
Parkin is activated through phosphorylation of ubiquitin by PINK1
Summary
A commentary on Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases by Riley BE, Lougheed JC, Callaway K, Velasquez M, Brecht E, Nguyen L, et al Nat Commun (2013) 4:1982. doi:10.1038/ ncomms2982. Parkin mutations cause deregulation of the mitochondrial homeostasis mechanism and subsequent accumulation of the impaired mitochondria and have a role in cell surface signaling and tumor suppression (3, 4). Neuroprotective therapy development in PD has been frustratingly slow, partially due to the lack of knowledge of the precise structure of potential target molecules, such as alpha-synuclein, LRRK2, or Parkin.
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