Will Aglepriston treatment in a dog affect its hormonal status throughout life?

Abstract

In this case, pre/postoperatively clinical and laboratory findings at the case of swelling of a long time mammary glands in 22 month old Labrador Retriever breed bitch were presented Veterinary Faculty Animal Hospital. In the anamnesis, it was learned that the size of the mammary glands although it has been four months since oestrus symptoms and that aglepriston was used to stay pregnant and terminate the pregnancy in the previous oestrus. Physical examination revealed that the mammary glands were hyperplasic from cranial to caudal and increased to normal. Palpation showed that the mammary glands had a soft consistency and milk came from the mammary gland. Mammary gland ultrasonography and lung radiography showed no pathological condition. Blood serum prolactin and progesterone measurements were recorded. According to the clinical and laboratory findings; it was diagnosed as pseudopregnancy and treated with cabergoline and daisy tea. Repeated enlargements of the mammary gland were observed in the same manner and durations during the sexual cycle follow-ups performed for one year. No macroscopic mass or adverse condition was observed in mammary glands during treatment and follow-up. In conclusion, aglepriston, one of the exogenous agents used to terminate pregnancy at an early age before complete sitting of hormonal development; Dogs caused irregularities in their sexual cycles throughout their lives, suggesting that suspected hormonal balance may predispose to various disorders in the future.