Abstract
Via different committed progenitors, hematopoietic stem cells produce all mature blood cells. The classical model of hematopoiesis predicts multiple binary bifurcations, the first of it resulting in the separation of lymphoid and myeloid cell lineages. Combining complex flow cytometric analyses, fluorescent cell sorting and functional single cell analyses, we recently uncovered unexpected lineage relationships in human hematopoiesis, which let us propose a revised model for human hematopoiesis.
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