Abstract
Background: We aimed to study the bilateral choroidal thickness (CT) symmetry and difference in uncomplicated pachychoroid subjects using wide-field swept-source optical coherence tomography (SS-OCT). Methods: All subjects underwent a wide-field 16-mm one-line scan using SS-OCT. Bilateral CT was measured at, and compared among, the following 12 points: three points at 900-µm intervals from the nasal optic disc margin (nasal peripapillary area), one point at the subfovea, six points at 900-µm intervals from the fovea to the nasal and temporal areas (macular area), and two peripheral points 5400 and 8100 µm from the fovea (peripheral area). Results: There were no statistically significant differences in CT between the right and left eyes in any area (all p > 0.05); they all showed significant positive correlations (all p < 0.01). However, the correlation coefficients (ρ) were smaller for the nasal peripapillary and peripheral areas compared to the macular area. Conclusions: The CTs in each region were bilaterally symmetrical in subjects with uncomplicated pachychoroid. However, interocular difference in CT increased from the center to the periphery, indicating that the anatomical variation of the nasal peripapillary and peripheral choroid was greater than that of the macula.
Highlights
The rapid development of optical coherence tomography (OCT) has shed light on the morphological and pathophysiological features of various chorioretinal diseases [1]
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The final study population consisted of 33 subjects with bilateral uncomplicated pachychoroid (22 men and 11 women) and an average age of
Summary
The rapid development of optical coherence tomography (OCT) has shed light on the morphological and pathophysiological features of various chorioretinal diseases [1]. Detailed analysis of the choroid using these state-of-the-art imaging techniques has led to new concepts, such as “pachychoroid” and “pachychoroid disease spectrum”. The pachychoroid disease spectrum, first introduced by Warrow et al [5], is characterized by increased focal or diffuse choroidal thickening, a pathologically dilated vein in Haller’s layer (pachyvessel) and thinning in Sattler’s layer and the choriocapillary layer [6,7,8]. The pachychoroid disease spectrum includes pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), polypoidal choroidal vasculopathy (PCV), focal choroidal excavation, and peripapillary pachychoroid syndrome [7]. An abnormally thick choroid without these specific findings on retinal imaging is referred to as uncomplicated pachychoroid [7,8,9,10]. Several studies have proposed cutoff choroidal thickness (CT) values to define a thick choroid
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