Abstract
In vivo confocal microscopy (IVCM) is a non-invasive imaging technique facilitating real-time acquisition of images from the live cornea and its layers with high resolution (1–2 µm) and high magnification (600 to 800-fold). IVCM is extensively used to examine the cornea at a cellular level, including the subbasal nerve plexus (SBNP). IVCM of the cornea has thus gained intense interest for probing ophthalmic and systemic diseases affecting peripheral nerves. One of the main drawbacks, however, is the small field of view of IVCM, preventing an overview of SBNP architecture and necessitating subjective image sampling of small areas of the SBNP for analysis. Here, we provide a high-quality dataset of the corneal SBNP reconstructed by automated mosaicking, with an average mosaic image size corresponding to 48 individual IVCM fields of view. The mosaic dataset represents a group of 42 individuals with Parkinson’s disease (PD) with and without concurrent restless leg syndrome. Additionally, mosaics from a control group (n = 13) without PD are also provided, along with clinical data for all included participants.
Highlights
Background & SummaryNeurological disorders are a significant cause of disability and death worldwide
In the period from 1990 to 2015, the number of deaths from neurological disorders increased by 36.7%, with Parkinson’s disease (PD) constituting the 12th most common condition leading to premature death (1.2%) among all neurological disorders in the overall global burden from neurological disorders in 20151
Restless legs syndrome (RLS), a sensorimotor condition, is frequently reported among patients suffering from neurological disorders including PD; occurrence of restless legs syndrome (RLS) as comorbidity in PD patients has been the focus of multiple studies[5,6,7,8]
Summary
Neurological disorders are a significant cause of disability and death worldwide. In the period from 1990 to 2015, the number of deaths from neurological disorders increased by 36.7%, with Parkinson’s disease (PD) constituting the 12th most common condition leading to premature death (1.2%) among all neurological disorders in the overall global burden from neurological disorders in 20151. Quantitative measures derived from non-invasive peripheral nerve imaging in the corneal subbasal nerve plexus are being reported as putative indicators of small fiber peripheral neuropathy in conditions such as diabetes mellitus[9,10,11,12,13,14,15,16,17]. This technique is of interest in the context of PD and RLS. To the best of our knowledge, no prior study in PD has investigated the inflammatory cells that are clearly visible at the level of the SBNP, in other conditions these inflammatory cells (such as antigen-presenting dendritic cells) have been shown to be related to the onset of disease[35]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
