Abstract
We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm(2) field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations within the oral cavity. Image quality of 2-dimensional image slices through the data can be greatly enhanced by averaging over the orthogonal dimension to reduce speckle. Initial in vivo imaging results reveal a wide-field view of features such as epithelial thickness and continuity of the basement membrane that may be useful in clinic for chair-side management of oral lesions.
Highlights
Worldwide in 2015, it is estimated that there will be over 325,000 new cases of, and over 157,000 deaths attributable to oral and lip cancer [1], with the majority of these being squamous cell carcinoma [2, 3]
Ex vivo studies have reported the ability of Optical coherence tomography (OCT) to define cancer boundaries [6], and measure changes in tissue features associated with oral cancer diagnosis such as the thicknesses of the keratin layer, epithelial layer, and lamina propria, as well as identify the continuity of the basement membrane [7,8,9]
The sample arm consists of a fiber optic rotary joint (FORJ, MJP-SAPB, Princetel Inc; Pennington, NJ) connected to a 0.9 mm outer diameter (OD), rotary-pullback catheter
Summary
Worldwide in 2015, it is estimated that there will be over 325,000 new cases of, and over 157,000 deaths attributable to oral and lip cancer [1], with the majority of these being squamous cell carcinoma [2, 3]. Immediate or real-time clinical imaging of these tissue features in the oral cavity may have useful applications for cancer detection and management. In the former, in vivo imaging of large suspicious oral lesions may indicate whether biopsy is necessary or guide clinicians to the sites that are most diagnostically useful. Ex vivo studies have reported the ability of OCT to define cancer boundaries [6], and measure changes in tissue features associated with oral cancer diagnosis such as the thicknesses of the keratin layer, epithelial layer, and lamina propria, as well as identify the continuity of the basement membrane [7,8,9]. Polarization-sensitive OCT has been combined with fluorescence imaging of the oral mucosa [19]
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