Abstract
Shen et al. assessed the impact of matrix metalloproteinases (MMP)-2 and -9 as well as collagen synthesis and degradation on in stent stenosis.1 In an animal study, they implanted Z-stents into the common iliac arteries of 60 Guangxi Bama mini-pigs. The affected iliac artery segments were assessed after 10 different time intervals between six hours and 336 days, leading to an appropriate overview of the endothelial changes related to the foreign body reaction. During the favourably long observation period, the authors observed that insufficient secretion of MMP-2 and -9, as well as excessive production or insufficient degradation of collagen, may be the cause of in stent restenosis (ISR), which reached its peak after two months.
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