Abstract
Determinants of the duration of opioid use after surgery are under- reported. We hypothesized that independent of pain, validated measures of preoperative psychological distress would predict more durable and prolonged opioid use following surgery. Between January 2007 and April 2009 a prospective longitudinal inception cohort study measured psychological distress and substance abuse preoperatively, and opioid use longitudinally following surgery. 109 of 134 consecutively approached patients scheduled to undergo mastectomy, lumpectomy, thoracotomy, total knee replacement, or total hip replacement consented to participate.
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