Abstract
Hematopoietic microenvironment or niche keeps stem cells in multi-potent/ uni-potent state which prevents precocious differentiation. The niche employs a variety of factors includes growth factors, cytokines and cell adhesion molecules too. In this section, we try to have a better understanding about the role of hematopoietic stem cells, niche and hematopoiesis as well as we demonstrate that leukemia induced reprogramming initially and then remodeling of the bone marrow (BM) microenvironment which can be a major part of leukemogenesis and is a potential prognostic parameter in malignant hematopoietic disease as well.
Highlights
As per our knowledge HSCs provide homeostatic maintenance of the blood system through their ability to differentiate and generate the hundreds of millions of erythrocytes and leukocytes needed per day
HSC niche consists of complex components including heterogeneous cell populations, growth factors and extracellular matrix molecules which is essential to regulate in the survival, quiescence, migration, differentiation and maturation of the stem cells [1-3, 25]
We have focused on the cells in bone marrow (BM) niche includes mesenchymal stem cells(MSCs), endothelial cells(ECs) and osteoblasts which suggesting that the fate of stem cells is determined by their interaction with the microenvironment they reside in
Summary
As per our knowledge HSCs provide homeostatic maintenance of the blood system through their ability to differentiate and generate the hundreds of millions of erythrocytes and leukocytes needed per day. Cell niches play essential roles for self- renewal and differentiation of HSCs in vivo and hematopoietic microenvironment show to generate functional hematopoietic stem cells.
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