Why is connectivity in barrel cortex different from that in visual cortex? - A plasticity model.

Abstract

Event Abstract Back to Event Why is connectivity in barrel cortex different from that in visual cortex? - A plasticity model. Claudia Clopath1*, Lars Busing2, Eleni Vasilaki3 and Wulfram Gerstner3 1 LCN , Switzerland 2 Graz University for Technology , Austria 3 EPFL, LCN, Switzerland Electrophysiological connectivity patterns in cortex often show a few strong connections in a sea of weak connections. In some brain areas a large fraction of strong connections are bidirectional, in others they are mainly unidirectional. In order to explain these connectivity patterns, we use a model of Spike-Timing-Dependent Plasticity where synaptic changes depend on presynaptic spike arrival and the postsynaptic membrane potential, filtered with two different time constants. The model describes several nonlinear effects in STDP experiments, as well as the voltage dependence of plasticity under voltage clamp and classical paradigms of LTP/LTD induction. We show that in a simulated recurrent network of spiking neurons our plasticity rule leads not only to development of localized receptive fields, but also to connectivity patterns that reflect the neural code: for temporal coding paradigms with spatio-temporal input correlations, strong connections are predominantly unidirectional, whereas they are bidirectional under rate coded input with spatial correlations only. Thus variable connectivity patterns in the brain, mainly unidirectional in barrel cortex versus bidirectional in visual cortex, could reflect different coding principles across brain areas. Conference: Computational and Systems Neuroscience 2010, Salt Lake City, UT, United States, 25 Feb - 2 Mar, 2010. Presentation Type: Poster Presentation Topic: Poster session II Citation: Clopath C, Busing L, Vasilaki E and Gerstner W (2010). Why is connectivity in barrel cortex different from that in visual cortex? - A plasticity model.. Front. Neurosci. Conference Abstract: Computational and Systems Neuroscience 2010. doi: 10.3389/conf.fnins.2010.03.00220 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Mar 2010; Published Online: 04 Mar 2010. * Correspondence: Claudia Clopath, LCN, Lausanne, Switzerland, c.clopath@imperial.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Claudia Clopath Lars Busing Eleni Vasilaki Wulfram Gerstner Google Claudia Clopath Lars Busing Eleni Vasilaki Wulfram Gerstner Google Scholar Claudia Clopath Lars Busing Eleni Vasilaki Wulfram Gerstner PubMed Claudia Clopath Lars Busing Eleni Vasilaki Wulfram Gerstner Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.