Abstract
Why Do Chemotherapeutic Drugs and Radiation Induce Cardiomyopathy and Cardiac Failure in Cancer Patients: Is this a Consequence of Unrecognized Hypomagnesemia and Release of Ceramides and Platelet-Activating Factor?
Highlights
Why Do Chemotherapeutic Drugs and Radiation Induce Cardiomyopathy and Cardiac Failure in Cancer Patients: Is this a Consequence of Unrecognized
We have shown that dietary deficiencies in Mg in rabbits and rats cause vascular remodeling(i.e., arteriolar wall hypertrophy and alterations in the matrices of the vascular walls) concomitant with atherogenesis, high blood pressure, and microvascular vessel vasospasm
A number of investigators employing intravital microscopy techniques, similar to those used in our laboratorieshave demonstrated that platelet-activating factor (PAF) increased the numbers of white blood cells in the microvessels concomitant with intense vasoconstriction-spasms with increasing concentrations of the putative lipid mediator (i.e., PAF), and less leukocyte rolling along the endothelial cell surfaces wth increased venular-postcapillary permeability Interestingly, we have found that ceramides can produce almost identical phenomena in a variety of microvascular beds, in vivo, when studied by high-resolution video microscopy
Summary
Why Do Chemotherapeutic Drugs and Radiation Induce Cardiomyopathy and Cardiac Failure in Cancer Patients: Is This a Consequence of Unrecognized Hypomagnesemia and Release of Ceramides and Platelet-Activating Factor?.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
