Abstract
New approaches to treating cancers are needed. Preclinical studies have identified numerous candidate genes/proteins that promote the cancer process. Cyclooxygenase-2 (COX-2) is a reasonable "target" because it is found in many epithelial tumors, has been shown to portend a poor prognosis, and is involved in many processes that promote cancer progression and chemotherapy resistance. Inhibition of COX-2 also has the potential to provide supportive care to patients with cancer. This article describes the rationale for performing a phase II trial of specific COX-2 inhibition in combination with chemotherapy to define toxicity and efficacy. However, as with most new therapies, phase III trials will be needed to determine whether specific COX-2 therapy is able to improve patient outcome with a reasonable safety profile.
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