Abstract
The thermal stability and thermal activity of four G90D rhodopsin isomer models were investigated by QM/MM method. The results implied that one pathological mechanism of congenital stationary night blindness caused by G90D mutation is the low thermal isomerization barrier of G90D rhodopsin binding with 11-cis retinal, not just the lacking of natural salt bridge. 9-cis retinal binding with G90D rhodopsin opsin could increase the thermal stability and minimize the thermal isomerization of G90D rhodopsin mutant. Therefore, 9-cis retinal was suggested to be used in potential treatments for congenital stationary night blindness caused by G90D mutation.
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