Abstract
Why are pyramidal cell firing rates increased with aging, and what can we do about it?
Highlights
Altered neuronal morphology and electrophysiological function in aged primates are correlated with cognitive deficits [1]
Ronal function characterized by action potential (AP) firing rate, somatic input resistance, AP firing rate adaptation, electrotonic lengths, and transfer impedance, is determined in terms of unitless measures
Through compartment modeling of these neurons, we extract aspects of altered morphology and electrophysiology that are central to age-related deterioration in cognitive function
Summary
Altered neuronal morphology and electrophysiological function in aged primates are correlated with cognitive deficits [1]. Published: 11 July 2008 BMC Neuroscience 2008, 9(Suppl 1):P51 doi:10.1186/1471-2202-9-S1-P51 Recent experimental studies of young and aged layer 2/3 pyramidal neurons of the prefrontal cortex (PFC) of rhesus monkeys show an age related increase in both the somatic input resistance and action potential (AP) firing rate [1].
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