Whole-body and part-body turnover of 85Sr in Paget's decease

Abstract

The whole-body and part-body retention of 85Sr has been measured over aperiod of 150 days in 12 patients with Paget's disease, seven of whom were treated withcalcitonin, starting 60 days after the 85Sr administration. Retentions were compared withthose in a group of seven control subjects. The retention data were analysed using multipleexponential, single and double power-law and combined power law and exponentialfunctions. The mean retention of 85Sr over a long period was greater in the Paget'spatients than in the controls, 1.9 times at two months. No significant effect of calcitonintreatment was demonstrated. Part-body measurements based on profile scanning demon-strated a significantly increased uptake of 85Sr in sites where disease was present. Thelonger-term rate of disappearance from such sites was faster than from unaffected bones.