Abstract
ObjectivesThe aim of this study is to characterize an NDM-1-producing Acinetobacter seifertii isolates from a patient in South Korea. MethodsAntibiotic susceptibility testing and genotyping using multigene sequencing were performed and whole plasmid sequences were determined. ResultsThe genotype of A. seifertii was ST1899, and was resistant to ceftazidime, trimethoprim-sulfamethoxazole, and piperacillin-tazobactam, in addition to carbapenem. blaNDM-1 was surrounded by ISAba125 insertion sequence within the structure of Tn125 in the 47 kb-sized plasmid. The plasmid exhibited a structure similar to that of other plasmids of diverse Acinetobacter species found worldwide. Transconjugation and growth curve indicated that the plasmid was adapted to A. seifertii rather than other closely related Acinetobacter species. ConclusionAcquisition of the carbapenem resistance by horizontal transfer of the blaNDM-1-carrying plasmid from another Acinetobacter species with no growth defect.
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