Abstract
ABSTRACTWhole-genome sequencing has emerged as a powerful tool to map genetic diversity among Mycobacterium tuberculosis isolates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission. Isolate LJ319 of the Mycobacterium tuberculosis complex (MTC)-Beijing genotype circulating in Maharashtra, India, which was obtained from the cerebrospinal fluid (CSF) of an immunocompetent patient, was subjected to whole-genome sequencing.
Highlights
Whole-genome sequencing has emerged as a powerful tool to map genetic diversity among Mycobacterium tuberculosis isolates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission
Highquality reads were mapped to the genome of reference strain M. tuberculosis H37Rv
The National Center for Biotechnology Information (NCBI) Prokaryotic Genome Annotation Pipeline was used for the annotation of the reference assembly
Summary
Whole-genome sequencing has emerged as a powerful tool to map genetic diversity among Mycobacterium tuberculosis isolates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission. The paired-end sequencing was performed on an Illumina MiSeq platform. Highquality reads were mapped to the genome of reference strain M. tuberculosis H37Rv
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