Abstract
Here, we report the draft genome sequence of the Gram-negative strain Klebsiella pneumoniae RYC492, which produces the amyloid-forming and antibacterial peptide microcin E492. The sequenced genome consists of a 5,095,761-bp assembled open chromosome where the gene cluster for microcin production is located in a putative 31-kb genomic island flanked by sequence repeats and containing a putative integrase-coding gene.
Highlights
We report the draft genome sequence of the Gram-negative strain Klebsiella pneumoniae RYC492, which produces the amyloid-forming and antibacterial peptide microcin E492
Microcin E492 (MccE492) is a bacteriocin produced by Klebsiella pneumoniae RYC492, a Gram-negative strain [1] that is active against members of the Enterobacteriaceae family [2]
MccE492 is toxic and induces apoptosis in malignant human cell lines [3]; it aggregates into amyloid-like fibers, thereby modulating its antibacterial properties [4, 5], and its C terminus can be postranslationally modified with salmochelin-like molecules [6, 7]
Summary
We report the draft genome sequence of the Gram-negative strain Klebsiella pneumoniae RYC492, which produces the amyloid-forming and antibacterial peptide microcin E492. Microcin E492 (MccE492) is a bacteriocin produced by Klebsiella pneumoniae RYC492, a Gram-negative strain [1] that is active against members of the Enterobacteriaceae family [2]. The genetic determinants for MccE492 production are located in the chromosome of K. pneumoniae RYC492, clustered in a ~13,000-bp segment, which was cloned and studied in Escherichia coli [8, 9].
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