Abstract
Selective breeding of cattle increases the level of inbreeding and, as a result, the risk of transmitting deleterious recessive alleles in a population. Numerous genetic disorders have been identified in various breeds of cattle. Although these disorders occur sporadically, the widespread use of semen from carrier sires can increase their prevalence in a population. In this regard, routine testing and elimination of carrier bulls is essential. The availability of a large amount of genomic data enables the screening and identification of causal alleles in the absence of phenotypes. This study aimed to investigate the presence of candidate variants of genetic disorders in Hanwoo cattle using whole genome data. 16,970 cattle were genotyped using the 50K Illumina Bovine chip and imputed to the whole genome sequence level using reference data from 203 bulls. Genetic coordinates of previously reported mutations in cattle were obtained from the OMIA online database. The information was then used to screen for harmful alleles in Hanwoo cattle. Fortunately, we did not identify any candidate variants in the tested population. However, this study was limited to a small sample. Moreover, the reliability of the results could have been affected by low imputation accuracy and genotype liftover errors. In this regard, we recommend regular screening of the breeding cattle to minimize the prevalence of genetic disorders in Hanwoo cattle.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.