Abstract
A consistent bias in tree reconciliation methods is described that occurs when the inferred gene tree is not correct, casting doubt on previous conclusions about ancient duplications and losses in vertebrate genome history.
Highlights
The rate of mRNA decay is an essential element of post-transcriptional regulation in all organisms
Overview of the data To explore the role of mRNA decay during the intra-erythrocytic development cycle (IDC) of P. falciparum, we used microarrays to determine decay rates on a genome-wide scale at four distinct stages
Transcriptional shut off was achieved by addition of actinomycin D, which is known to intercalate into DNA and inhibit DNAdependant RNA polymerases [17]
Summary
The rate of mRNA decay is an essential element of post-transcriptional regulation in all organisms. Studies in several organisms found that the specific half-life of each mRNA is precisely related to its physiologic role, and plays an important role in determining levels of gene expression. Http://genomebiology.com/2007/8/7/R134 understanding of the molecular biology of P. falciparum is an important step toward the identification of new drug and vaccine targets. The P. falciparum 48-hour asexual intra-erythrocytic development cycle (IDC) is characterized by the progression of the parasite through several distinct morphologic stages: ring, trophozoite, and schizont. Each cycle begins with invasion of an erythrocyte by a merozoite, followed by the remodeling of the host cell in the ring stage. In the schizont stage, the parasite prepares for the round of invasion by replicating its DNA and packaging merozoites
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