Abstract
Whole-Genome Analysis of KPC-Producing Klebsiella Pneumoniae Isolates from Hospital Acquired Post-Neurosurgical Meningitis
Highlights
IntroductionPatients (especially in nervous system cancer patients who receive cancer care) due to exposure to various risk factors (such as catheters and tubes, neurological deterioration, multiple injuries and damage to the immune system) and more susceptible to hospital infections [1,2,3]
Patients due to exposure to various risk factors and more susceptible to hospital infections [1,2,3]
The results of molecular analysis showed that ST11 and IncFII-type plasmid in carbapenem-resistant Klebsiella pneumoniae (CRKP) have close correlations and indicate a long-term retrospective genomic study throughout the hospital for KPCproducing K. pneumoniae is necessary
Summary
Patients (especially in nervous system cancer patients who receive cancer care) due to exposure to various risk factors (such as catheters and tubes, neurological deterioration, multiple injuries and damage to the immune system) and more susceptible to hospital infections [1,2,3]. Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become one of the biggest global public health concerns [10, 11]. This study reports ten cases of post-neurosurgical nosocomial meningitis due to CRKP over three years; six isolate strains were further studied. From 2017 to 2019, every July to September, there were nosocomial meningitis outbreaks in cancer patients of central nervous system in our hospital’s neurosurgery department; the culprit was identified as CRKP. This report is the first CRKP meningitis outbreak in cancer patients described in central China [12, 13]. Nosocomial bacterial infections from carbapenem-resistant Klebsiella pneumoniae (CRKP) are associated with high mortality in neurosurgical patients. This study examined the post-neurosurgical meningitis outbreak caused by CRKP of patients with nervous system tumours,and analysed the molecular characteristics of the causative strain
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