Abstract
If the great biochemists Krebs, Embden, and Meyerhof were discovering today the metabolic pathways that bear their names, they might be outfitting their labs with nuclear magnetic resonance instruments. A few labs in the U.S. already are devoting NMR instruments to biochemical problems, instigating what might become a neoclassic era of interest in metabolic pathways and their control by enzyme modulation. At least two labs, one in New Jersey and the other in Texas, are studying biological systems with carbon-13 NMR. The information that they can extract with this method rivals the classic use of radioactive labels, such as carbon-14 and hydrogen-3 (tritium) to probe cell metabolism. Both labs, the one in New Jersey directed by Dr. Robert G. Shulman of Bell Laboratories in Murray Hill, and the other by Dr. A. Ian Scott of Texas A&M University, College Station, already seem swamped with more good projects than they can ...
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