Abstract
Antimicrobial Peptides (AMPs) have been studied for more than two decades because they promise to help overcome the problem of resistance conventional antibiotics. However, AMPs have not been as successful as hoped, perhaps because we lack a detailed understanding of their mechanisms of action. To understand these mechanisms, numerous biophysical techniques, including solid-state 2H NMR, have been used to study membrane disruption both in model lipid system and in intact bacteria. In the real biological context of AMPs, studies have suggested that, in addition to interaction with lipids, it is essential to consider the non-lipid component of Gram-negative bacteria.
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