Whole-brain electrophysiological functional connectivity dynamics in resting-state EEG

Abstract

Objective. Functional connectivity (FC) dynamics have been studied in functional magnetic resonance imaging (fMRI) data, while it is largely unknown in electrophysiological data, e.g. EEG. Approach. The present study proposed a novel analytic framework to study spatiotemporal dynamics of FC (dFC) in resting-state human EEG data, including independent component analysis, cortical source imaging, sliding-window correlation analysis, and k-means clustering. Main results. Our results confirm that major fMRI intrinsic connectivity networks (ICNs) can be successfully reconstructed from EEG using our analytic framework. Prominent spatial and temporal variability were revealed in these ICNs. The mean dFC spatial patterns of individual ICNs resemble their corresponding static FC (sFC) patterns but show fewer cross-talks among distinct ICNs. Our investigation unveils evidences of time-domain variations in individual ICNs comparable to their mean FC level in terms of magnitude. The major contributors to these variations are from the frequency below 0.0156 Hz, in the similar range of FC dynamics from fMRI data. Among different ICNs, larger temporal variabilities are observed in the frontal attention and auditory/visual ICNs, while sensorimotor, salience, and default model networks showed less. Our analytic framework for the first time revealed quasi-stable states within individual EEG ICNs, with various strengths or spatial patterns that were reliably detected at both group and individual levels. These states all together reveal a more complete picture of EEG ICNs: (1) quasi-stable state spatial patterns as a whole for each EEG ICN are more consistent with the corresponding fMRI ICN in terms of the bilateral distribution and multi-nodes structure; (2) EEG ICNs reveal more transient patterns about within-ICN between-node communications than fMRI ICNs. Significance. The present findings highlight the fact that rich temporal and spatial dynamics exist in ICN that can be detected from EEG data. Future studies might extend investigations towards spectral dynamics of EEG ICNs.