Abstract
An eleven-year-old Galgo Espagnol was diagnosed with metastasized anal sac adenocarcinoma. The patient was enrolled into a clinical trial and underwent three “whole-body thermal therapy” (WBTT) sessions combined with four hypofractionated radiotherapy sessions during a ten-weeks’ time period. The medical device and corresponding treatment protocol were designed by ElmediX (ElmediX NV, Belgium). Air was injected at high speed in a treatment chamber and automatically regulated to reach and maintain a body temperature of 41.5°C for eight hours. Thermometry was ensured by temperature sensors placed in and on the patient. During four radiotherapy sessions, an external beam delivered hypofractionated doses of 6Gy on both the primary tumor and the metastatic lymph nodes. Clinical monitoring and assessment of quality of life confirmed that the WBTT sessions were well tolerated. Although burn wounds at pressure points occurred, prolonged severe adverse effects were not observed. Furthermore, the disease progression was deemed slower than the expected progression based on the literature.
Highlights
An eleven-year-old, female, spayed, Galgo Espagnol was presented to the Veterinary Hospital of the Faculty of Veterinary Medicine (Ghent University, Belgium), to be enrolled as a presumed healthy dog in a doctoral project studying early detection of kidney disease in senior dogs
Fine-needle aspirations of the anal sac nodule and of the right medial and right internal iliac lymph nodes were obtained under ultrasound guidance
Chemotherapy and radiotherapy were declined by the owners because they were worried about the possible side effects in their apparently healthy dog
Summary
An eleven-year-old, female, spayed, Galgo Espagnol was presented to the Veterinary Hospital of the Faculty of Veterinary Medicine (Ghent University, Belgium), to be enrolled as a presumed healthy dog in a doctoral project studying early detection of kidney disease in senior dogs. Because blood pressure measurements with a Doppler probe and inflatable cuff during hospitalization revealed that hypotension was still present (data not shown), the dopamine CRI remained ongoing until the patient was able to maintain its own blood pressure.
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