Abstract
A derivative of tetracycline was tagged with 131I and administered to rats. Whole body retention of the tetracycline was determined by sequential measurements of whole body radioactivity. Statistically significant differences of whole body burdens were found for two age groups of rats (100 g. versus 200 g.); the younger animals retaining a greater portion of the administered tetracycline. Subsequent distribution analysis indicated that whole body radioactivity measurements did not precisely assess skeletal burdens of 131I-labeled tetracycline because variable amounts of tetracycline persisted in soft tissue for prolonged intervals after injection, but did provide estimates of skeletal burdens which could be used to recognize differences in skeletal growth rate between groups of young and mature rats. The whole body counting technique may be applicable for the study of metabolic skeletal disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
