Abstract
Whole bladder wall photodynamic therapy, using hematoporphyrin derivative as a sensitizer, the red light (wavelength 630nm) and a newly designed light-scattering device was carried out in a total of 12 patients with superficial multicentric bladder tumors with/without carcinoma in situ of the bladder. The total light dose was 10 Joules/cm2 to 30 Joules/cm2 except 216 Joules/cm2 in one patient. Clinical responses were evaluated by selected-site mucosal biopsies and cystoscopy 4 weeks after the treatment. The anticancer effect of photodynamic therapy was followed by urinary cytology and cystoscopic examination for 14 months. Out of the 12 patients, complete response defined as no malignant cells in all biopsies was attained in 8 patients. Out of the 12 patients no recurrence of bladder tumors developed in 6 patients with a mean tumor free time of 6 months.
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