Abstract
Whole eye visualization and morphometry are of high relevance in clinical practice. However, most standard ophthalmic OCT instruments are dedicated either to retinal or to anterior segment imaging. We demonstrate a swept source optical coherence tomography system (SS-OCT) that images both the whole anterior segment and the retina alternately using a single source and detector. A pilot population was imaged with the proof of concept prototype. We demonstrate the clinical potential of whole eye OCT screening for the description and early detection of relevant clinical features in the anterior segment and retina of several patients.
Highlights
Optical coherence tomography (OCT) is a noninvasive technique that permits to generate crosssectional and volumetric images of the human eye with micrometer resolution
We have demonstrated a whole anterior segment and retinal swept source OCT (SS-OCT) system
The results showed its utility in the description of clinical findings in the retina and the anterior segment of both symptomatic and asymptomatic volunteers
Summary
Optical coherence tomography (OCT) is a noninvasive technique that permits to generate crosssectional and volumetric images of the human eye with micrometer resolution. Other implementations permitted to image the retina with a wider field of view thanks to an adapted interface for retinal imaging in the sample arm, combined with the anterior segment one using two beam splitters or polarization multiplexing (two orthogonal polarization modes propagate through two dedicated interfaces for retinal and anterior segment imaging) In these works, either only the anterior chamber is imaged [11] or entire anterior segment visualization is achieved by employing off-pivot based complex conjugate removal [12] and full range complex (FRC) SD-OCT [13]. An electrically tunable lens changed power on a B-scan basis permitting to enhance the visualization of structures at different depths Another solution for the interferometric limitation of OCT systems proposed the use of successive coherence revival windows of short cavity lasers [16] and was used to image the anterior segment and retina without the need of adapting the reference arm [17]. Visualization of the whole anterior segment and the retina enables whole eye screening on a single instrument, which provides a comprehensive description of features of clinical relevance all over the ocular structures
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