WHO-recommended Antibiotics for Infant Sepsis Lack Efficacy

Abstract

Downie L, Armiento R, Subhi R, et al. Community-acquired neonatal and infant sepsis in developing countries: efficacy of WHO’s currently recommended antibiotics – systematic review and meta-analysis. Arch Dis Child. 2013; 98( 2): 146- 154; doi: 10.1136/archdis-child-2012-302033[OpenUrl][1][Abstract/FREE Full Text][2] Researchers from the University of Melbourne, Australia conducted a systematic review of data on the etiology and antimicrobial susceptibility of community-acquired bacterial sepsis (CABS) in neonates and infants 1 to 12 months of age from developing countries in order to evaluate the efficacy of current World Health Organization (WHO) guidelines for empirical antimicrobial therapy in this population. The treatment guidelines recommend first-line therapy with penicillin or ampicillin plus gentamicin for infants aged 0 to 2 months and penicillin plus chloramphenicol for older infants. Flucloxacillin and third-generation cephalosporins (CEF3G) are recommended as second-line agents.1 ### PICO Question : Among neonates and infants from developing countries, what are the causes and antimicrobial susceptibilities … [1]: {openurl}?query=rft.jtitle%253DArch%2BDis%2BChild%26rft_id%253Dinfo%253Adoi%252F10.1136%252Farchdischild-2012-302033%26rft_id%253Dinfo%253Apmid%252F23142784%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=archdischild&resid=98/2/146&atom=%2Faapgrand%2F29%2F3%2F28.atom