Abstract

The discovery of insulin is commonly thought to be the result of a single brilliant idea of a young Canadian physician. The reality is far more complex, and careful historical research has revealed formidable scientific and human complications. Examination of relevant documents and laboratory notebooks has made it possible to reconstruct a complete history of the discovery, including the day-to-day experimental work with its progress and failures, and in the end to pinpoint the contributions that led to success. These events did not develop in peaceful harmony; there were incriminations and dramatic personality clashes.

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