Abstract
ABSTRACTWe explored who wrote the milestone articles in the innovation processes of immune‐checkpoints CTLA‐4 and PD‐1. In order to map the processes, a literature inter‐citation network analysis was made through HistCite and Pajek. We found knowledge flow through citations between topics (clusters), transverse knowledge diffusion between topics at the same basic research level and knowledge translation from basic research to clinical research. Betweenness Centrality showed a good performance in selecting key nodes of knowledge flow.
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