Abstract
Paenisporosarcina quisquiliarum 17mud 1‐1541 (designated to KCTC13860BP), an extremophilic radiation‐resistant bacterium, was newly isolated from the mud in coastal areas of Korea. The aim of this study was to evaluate the whitening effects of 17mud 1‐1541 extracts. The viability of B16F10 cells was evaluated by MTT assay to determine the non‐toxic doses for further experiments. The contents of melanin and the cellular pigmentation images were evaluated. To confirm 17mud 1‐1541 mechanism in melanogenesis, cellular tyrosinase, L‐DOPA, and α‐glucosidase activities were determined. 17mud 1‐1541 has strong inhibitory effects on melanin production and cellular tyrosinase activity in α‐MSH‐induced B16F10 cells. Melanogenesis‐related factors such as L‐DOPA oxidation, tyrosinase and α‐glucosidase activities were all reduced in the presence of 17mud 1‐1541. Overall, 17mud 1‐1541 has a whitening effect due to inhibition of melanogenesis, which is affected by α‐glucosidase and tyrosinase inhibition activities. Our findings suggest that 17mud 1‐1541 has a promising potential to be used as skin lightening agent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
